Do I need all of these Adobe Files on my computer? Safe to Delete?

Hi Everyone,

I have a ton of miscellaneous adobe files on my computer that are taking up space on my hard drive (seen in below image), is it alright for me to delete these or will it mess up my Adobe programs? If I can delete some of them, which ones are safe to delete vs. keep? As seen in "last accessed" some of them haven't been used since I downloaded Adobe onto my new computer in October. If I can't delete them, can anyone tell me what they are? Thanks!