Having a single SSD of 512Gb divided in two partitions on my laptop (C: and D:), I changed the default installation path of the programs in the registry to prevent my C: drive (80Gb) from being full too quickly.
Unfortunately and after having looked for the problem during long hours, it seems that this change of path is causing the malfunction of Adobe Creative Cloud.
When I install it it works the first time but as soon as I restart my computer, it loads during a few minutes and then this sadly famous error message appears :
"Adobe Creative Cloud, needed to resolve the problem, is missing or damaged. You can try to repair to fix the issue. If the problem persists, download and install the new copy from http://www.adobe.com/go/adobecreativecloudapp."
Interesting that you're having the exact same issue I've been struggling with since yesterday. Although in my case, I don't recall making any changes recently. However, I do have my programs (and Windows) both installed on an SSD under a "W:" partition rather than the usual "C:".
I've been having issues with the Creative Cloud app since about a week ago, with fonts not loading properly and whatnot. I tried to fix the issue yesterday by uninstalling and reinstalling Creative Cloud, and that's when it all came crashing.
After attempting everything from the cleaner tool, reinstalling Creative Cloud numerous times, contacting support and going through several other steps with the support team, the issue still persisted. After my last system reboot I got the exact same Asserton Failed message as you.
My guess is that it might have something to do with a recent Windows 10 update, but I could be wrong. Your thought on it being partition-related could very well be the issue.
I've concluded that the only way to avoid wasting more time would be to format my PC and reinstall everything - although it would be devestating if the issue persists after that.
I've asked Adobe Support for individual downloads for each software I currently need to finish my work. That could be a temporary solution to get your work done if you're in a rush.
Good luck! Here's to hoping we find a solution better than formatting...
I'm pretty sure this is partition related since it didn't work on Windows 10 for me (with the installation path changed in the registry), I then updated to Windows 11 and it worked again (but I had not changed the installation path yet) and stopped working as soon as I modified the Program Files path in the registry.
One quick solution for you could also have been, I think, to change back the installation path of softwares in the registry on the C: drive before reinstalling Creative Cloud. This worked for me but I don't want to have all my programs being installed on the C: drive which is almost full on my laptop.
Hoping someone will be able to provide us with a solution now !