Adobe software older than the Creative Cloud (CC) versions are not officially supported on macOS 10.14 Mojave. That doesn’t necessarily mean they won’t work; it just means that if those old versions have any new issues related to macOS 10.14 Mojave, there won’t be any updates to address them (in other words, the only version with the Mojave fixes will be the current version).
Based on how Adobe CS3–CS6 applications have run in other recent versions of macOS, it’s safe to say that they won’t run as smoothly as they did in earlier versions of macOS/OS X. The CS3–CS5 applications seem particularly risky to me. There are more hoops to jump through to get the installers to work, and some installers may not work at all.
Adobe doesn’t verify compatibility of older (pre-Creative Cloud) software because covering all of the features for multiple older versions would require extensive testing, and they were tuned for macOS code that has either changed dramatically or in some cases is simply not there any more. If you still depend on those old versions for serious production or need information about a specific feature (especially “does it work with my printer/tablet/scanner etc.”), you need to set up a test system to verify your workflow on Mojave before upgrading your production system (see How to test macOS 10.14 Mojave yourself). And if your tests determine that your programs won’t run well under Mojave but you want to upgrade, consider maintaining a system on a spare hard drive or partition just to run an older version of macOS for those applications.
Quote: https://blog.conradchavez.com/2018/09/24/macos-10-14-mojave-will-adobe-software-work/
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