Epub document to refresh page to play on-load animations

EPUB is extraordinarily dependent on the reader used, and it's rare for a book to appear or function the same on any two. That's true of plain text books, and multiplies rapidly when multimedia and interactive elements are added. If you're going to include multimedia elements, you're going to have to choose the reader for which to optimize the book, and repeat the process for any others you wish to have good results on.

Unless you are going to sell only on one platform (such as Apple), you should optimize your book for perfect rendering and function on Calibre or Thorium Reader — the latter is technically more standards compliant but has an annoying rendering bug that has gone unfixed for some time. It's then on every (human) reader to use Calibre, or another highly compliant reader, or put up with different rendering and functions, if not outright glitches. (For Apple, use their reader for proofing and optimization.)

I am getting the vibe that this is a fixed-page (FXL) EPUB as well, which brings other issues. Unless it's a picture-page book, FXL is a problematic, deprecated format. EPUBs — e-books in general — should be reflowable format unless there is an absolutely compelling reason to use fixed pages. Part of that is because reflowable books have many options for tweaking and fixing rendering and functional issues, while fixed books have, in practical terms, none.

But yes, EPUB does in theory support embedded multimedia. If the reader used does.