More M1 / InDesign headaches

Having read all the discussions about the problems with Adobe products vis a vis the new M1-chip Mac, I'm just throwing in another experience with it. I cannot explain how it happened, but InDesign started hanging yesterday, and became completely unusable. Then I started having more problems. My Finder started crapping out and needing to be relaunched, other apps started having the same problem.

I'd be tempted to put this on a problem with OS Monterey, except I was able to get everything fixed eventually, except for Adobe products (Acrobat also started to become non-functional). I've tried the Cleaner App limited success. I've opened InDesign after the clean-up and a new install, and I can open ID files from the Finder, but the Open command in the app itself doesn't work.

I will mention that there was one process or line that was still appearing in the Cleaner window, "Fix Host File," that the Cleaner tool wouldn't clean. It remained there after running the clean-up. I'll say that I didn't do a manual search for residual Adobe files after running the cleaner, but I can't say I have much confidence that doing all that work is going to make a difference if I do the whole clean-up again.

I'd offer more details if I didn't have a day job. I'm sorry, this is the best I can do. I don't know whether there's one more answer to this problem that's escaped my notice, or I'm just adding one more anecdote about the misery that is M1 vs Adobe.