Need help setting up card template that needs constant changes

Build an imposition template from scratch that I can edit by making changes on just one card without having to cut and paste onto the rest.Sent from device. Please excuse typos.
By @D A V A

Then like I've suggested - DataMerge - quicker and less hassle. 

You can prepare a database with all info - that you would have to prepare anyway - then use the template that you already have - then with one click fill it with data. 

But would be great if you would post more datails about you project / workflow + some screenshots of before & after - as right now we are just guessing... 

I get the feeling that some of the answers aren't quite addressing the OP's question. There are two stages here, as in most business card setups—

• Placement of individual info on each card (name, email,. phone, etc.) That can be handled several different ways, from simply typing in the infom across a six or eight card layout to using Data Merge for larger or more repetitive jobs.
• Editing the card's boilerplate info, including company name, address, number, division, main email address, etc. This has to change simultaneously on all cards.

I think the OP is looking for an efficient way to do the latter. I'd just the master card layout (a 2x3.5 inch layout for one card), placed as an INDD in as many iterations as needed on a combined print layout. This gets past all the complexity and limitation of cross-refs, variables, formatting, and even nuances such as changing a key graphic element's color, and ensures 100% consistency across the print layout. All the fixed text fields can be formatted as necessary, with interim highlighting or bolding etc., without having to jump through merge/GREP/style/variable hoops. Frames on each placed layout can then be edited/merged/managed in more conventional methods.

That's my interpretation of the need and an optimum solution.