Hi again. Calibre works well, but my book is made in 2 column text. Only pictures and picture captions may be over both columns. How Calibre reads and transforms that. I've got text from with InDesign made pdf...

And the result as ePub 3 in Calibre is:

Is there something to do?
A better reader will be a better platform to evaluate and adjust your exported EPUB, so using Calibre is a good step.
Using fixed-page EPUB, though, is a poor choice. EPUB has never been good at replicating print page layout without a lot of work and compromises. As Bob says, if you want digital images of your print layout, use PDF. It's far, far simpler and more universally supported for distribution and reading.
If you want or need an EPUB for specific reasons, such as being able to sell or distribute the book through vendors or online libraries, it should be reflowable and the content should be formatted to allow "liquid" layout in any reader, depending on its settings and the user's preferences. You can't usually force two columns, for example; in reflowable that's a reader setting, not a document aspect.