Magenta cast on prints

Printing from Lightroom Classic on a Macbook, to a Canon ImagePrograf Pro-300.  I'm using the Print tab, and at the very bottom, there is a section called Color Management.  If, in Color Management,  I select a paper profile I downloaded from the paper manufacturer, I get a magenta cast.  However, if I set Color Management  to "managed by printer," there is no magenta cast.  This is a sudden change.  I've printed using Lightroom to manage colors many times before.  From what I have read, this behavior means I'm I am somehow managing color from more than one source, but I cannot figure out what the sources could be.  

The only thing I have found that is different is that, when I choose to let the printer manage color, in the printer dialog under "color," the box for Canon color is checked, but if I choose a paper profile, and look at the print dialog under "color," then ColorSync is checked (see attached screen shots).

I admit I was poking around in the ColorSync application earlier today, trying to learn what it is/does, so I could have changed something.  I'm way out of my depth here.  Is there some way the operating system on my Macbook is managing color and interfering with Lightroom managing it?