When dragging a guide in from one of the edge rulers in a document, since about 1st August 2022, it somehow is now left selected as the active element of the document.
This means it's broken a considerable amount of workflow.
Drag a rectanguar marquee.
Drag a guide to snap to the edge of the marquee.
Ctrl-delete to fill the marquee.
This used to work. When you do it now, Ctrl-delete deletes the newly-created guide because it has been left as the active element, instead of filling the marquee which is what it should have done.
There's no way to de-select the guide without removing the marquee selection first. This is a significant change to the most basic functionality and has removed the ability to have selections in a document if you're trying to use guides.