I am on the latest Photoshop (as updated by Creative Cloud) and I keep having issues with preserving my preferences (for a long time - years).
After each Photoshop update, the "Set" in Keyboard preferences resets to "Photoshop Default" even though I have set up my custom Set and I have it active. Meaning after each update, I have to go there and switch it back to my custom set.
Today I opened up Photoshop just like normal (after closing it yesterday just like normal) and I found all my User Actions just... gone. No idea why, Creative Cloud says the last update was 21 days ago, but the actions just disappeared and the "Default Actions" are the only ones there (it simple reset to default). Also it looks like (some) UI panels reseted to default as well because I had to reopen Timeline for example and add Actions back to to side panel.