Adjustment layers stops work after a certain amount of time

Hi, 

So i have been searching online for hours about how to fix my problem with an adjustment layer and it seems the general issue is it being grayed out. For me that is not the case, I put adjustment layers onto my clips and they are normal and work the same way and then after two to three times of opening and closing my project and saving it, they seem to have no affect on my clips below them. I have read that you should copy and paste int a new project but after having to do that 4 times now, the adjustment layers take no more effect on my clips. The hardest part to figure out is that the adjustment layer is there and over my clip, but you cannot adjust anything on it to affect the clip below. And once these adjustment layers stop working, if I try to add a new one or create a new one, it has the same effect.

Let me know what I can do, Thank you!