Frame drops with mxf files on hi-spec machine - I need your help

Hi,

I have had a good dig for a number of days through the forums and internet and could use some help.

Problem:

We have just invested in a new hi-spec edit suite and are having frame drops while using mxf files.

Example of problem here:

https://drive.google.com/open?id=1_H9zUA0aTFMlZqpemc46hHNcowT0c363shadowplay dropped frames.mp4 - Google Drive

Specifications:

Processor Intel(R) Xeon(R) Gold 5120 CPU @ 2.20GHz, 2195 Mhz, 14 Core(s), 28 Logical Processor(s)

    Waiting on second cpu - currently running with as single cpu as above

Installed Physical Memory (RAM) 128 GB

NVIDIA GeForce GTX TITAN X - 12GB video ram

Windows 10 64 bit

Premiere Pro 12

M.2 500gb Boot and application drive

M.2 500gb cache drive

3TB 7200 rpm - media files

Benchmark

In the benchmark testing (amazing standardized test Bill) scored 130,69,26,215

From my research this seems to indicate that everything is where it should be apart from the graphics card under-performing using the comparison chart.

Problem defined:

The frame drops only appear while using mxf files. These files have been shot on Sony fs7 in 1080 and 4K, at variety of frame rates. All sizes and rates drop frames even at the lowest resolution in playback. This is in mixed sequences (frame rate/ frame size) and in clips with matching frame rates.

In playback the CPU GPU and memory sit at around 15% for 1080 and 30% for 4K. CPU jacks to 50-65% without cuda enabled.

A few times I have been able to get the edit suite to play mxf files in all resolutions. When it is stable I can push it to what it should be able to handle. However, as soon as I close PP and restart back to frame drops.

All these files have worked on our old edit suite with the exception of 4K having to be played at 1/2 resolution for no dropped playback (Old edit suite 24gb ram, geforce gtx 950, i7-3770 - windows 7).

What we have tried so far:

Fresh projects

Fresh profiles

Have tried a variety of mxf footage filmed over the last 6 months

using the media browser to import footage

Installing Avid quicktime LE codecs

Updated Nvidia drivers - also tried removing them all and re-installing

Switching between CUDA enabled/disabled

Enabling/Disabling all firewalls

Reinstalling premiere + Media encoder

Rolling back to premiere + media encoder 2017

Installed Avid Media Composer - no issue playing the mxf files, though avid does transcode on import (Thought the AVID PE codecs might help)

Ran off single screen

disabled audio while scrubbing

disabled mercury playback

Shifted audio preview cache to m.2 media cache

Uninstalled Realtek HD microsoft audio

updated all audio drivers

disabled composite preview during trim

Shifted project files to SSD

Powersaver to high performance

Quicktime Installed to latest

Quicktime rolled back to 7.7.6

Disable audio card

Disable nivida audio driver

I would appreciate any help. It is now day four of trying to fix this, I am going crazy, it is costing a lot of money and I have stories piling up.

It was meant to be faster, that's all I wanted.

Kind regards

Stu