Premiere Pro 2022 not running smooth after trying everything

Hello, 

I can't seem to get Premiere pro running smoothly on my system. When I'm editting and playing back, it keeps getting stuck/freezing and I can't play back properly. I've been trying everything:

1. I make proxies in the lowest quality possible with Media Encoder
2. I turn of FX
3. I have the playback quality set to lowest
4. Everything I could Google, I have tried (so also changing settings with the GPU, everything is on max and reserved for use with Premiere Pro). 
5. I render the selection before playing back

My system:

I use M2 memory (which has over 1tb of space), I have a watercooler on the CPU and it doesn't seem like anything is getting too hot. There's a software on my PC that shows me the load of the CPU and GPU and it doesn't cross 20 % on CPU and GPU and for the RAM it's about 60% (20GB) whilst playing back my timeline in Premiere Pro.

 I've attached my sequence settings. 

I work with multiple layers (about 30-40), mostly it's some sort of simple animation and I load in Illustrator Files, which I nest into short animations and then put together as a visual for my band. There's many many images in one nest (like 20-70) and sometimes they are not nested and just put behind each other, so I can still edit the animation frame by frame. So in total, there's a lot of Ai files in my Pr project.

When I'm working with video's from my Iphone (which are in high quality), it seems to run smoother, even if I copy everything until I have 40 layers. Although I've had some trouble editting a more advanced videoclip with video's from my phone, but I could work through it.

Any idea what might be the problem? Could it still be that my system can't handle the proejcts, although it doesn't seem like that with the software? I'm fairly new to working with biger projects, as I've only been learning working with Adobe for a few years now (on my own) and in the past year I've been starting to make lots of progress, which results in bigger projects. It's so bad now, that I have to export everything to see if it looks alright, then work on it, export, etc.

Any information missing, let me know!