The new Toggle Direct Manipulation is a feature I understand why it exists, for those users who don't really know the deep ins and outs of the program. But by changing it you have instead caused several more problems than you actually fixed.
1. If you had enabled Toggle Direct Manipulation then it remains on for all other clips you select. If you select a clip during playback, playback pauses as a result of the Toggle being on, and it must be turned off. Selecting and manipulating clips during playback is one of your biggest edges over, say, Avid.
2. Toggle Direct Manipulation can be enabled via a shortcut key inside of the Program Monitor, but that shortcut key only works if the Program Monitor is selected. It needs to work across all panels in the entire program so that it can be turned on and off at will, specifically from the timeline.
In previous iterations of Premiere I could hit a shortcut to enable manipulation, then do my work, and when I was done go back to editing with no further action needed, but now you've added the completely unnecessary extra step of turning it off.
The way it should work is that it is always off, all the time, and is only on when you turn it on. After you complete manipulation it should return to being off by default, and only be re-enabled if the user wants it to be.