Hello @NaoYuee,
Thank you for your message.
We've indeed received messages from different users facing crash at start up since the 15.0. Although we have some leads, we still don't understand exactly why the crash is occuring (yet).
It's possible that the integrated GPU is bringing all the trouble, even if it isn't used for running Substance Designer. Therefore, I strongly advise you to also update the integrated GPU (Radeon Graphics in your case), and let me know if it helps.
Best regar
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