Are you using smart previews? That might help speed things up. I have a similar setup, 190,000 images referenced in the single catalog that I use. That catalog does take a while to load on startup, but I have no slowness until I have been editing for several hours when LrC does slow down noticibly. I just restart and keep working at that point. My disk setup is two NVME SSD, one for OS (Win 11) and one for the LrC catalog and preview folders. See you system description in my signature. All my images are on internal hard drives of the appropriate size. LrC does not typically access the original raws except to create new 1:1 previews when you zoom in, or to export, or to print. It's working from previews at that point so smart previews might be helpful to you.
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