I don't think there is any issue of Adobe's servers here: with LR Classic the image processing happens only inside your local computer and that is where the result of generative AI is also stored.
Without seeing the particular message it is hard to be sure, but one issue to do with "guidelines" happens when you have applied a 'retouch' tool (that has used bits of your image content to infill / to patch an area) and then meanwhile changed the perspective appearance of the whole image. For example, by using "Guided Upright" - or, there are other tools that can raise the same issue.
The prompt may be warning you that an infill / patch which used to match up seamlessly with its surrounding image content, may no longer do so. In that case this infill / patch should now be updated (AI generation should be refreshed) so that it is again sure to show seamlessly within the picture.
You won't see this same prompt with simple cloning or spot healing, since in those cases the patching happens dynamically working from the live image only. AI generated retouch by contrast is not dynamic: it makes and then stores a static result at a certain moment - which can, accordingly, later become outdated.