@Dion34708647p3mw If your project is complex, it would no hurt to try migrating it to a Production. Based on where you are at with your troubleshooting, I would proceed with a clean install. If you're already using Time Machine, I would allow it to run for one more incremental backup. If not, I'd take the time to set it up and let it do one complete backup. Then, start with a clean instsall of macOS - including a reformat of the Macintosh HD. If project files or source footage is on your Macintosh HD, restore just the Documents from the Time Machine backup. Hopefully, though, those files are all on external storage.
Follow that with installing Creative Cloud Desktop and just Premiere Pro and Medie Encoder, but nothing else. I'd include both Premiere Pro 24.x and 25.x. Try opening a 25.x project and see what heppans. (It might not hurt to take the extra step of openign a new, empty project and then importing an existing project into it). Dismiss any notifications about missing effects or third-party extenstions and addons. If somehow 25.x does not behave as expected at this point, try a new project in Premiere Pro 24.x from scratch. For both 25.x and 24.x try to start with something that does not use Insta360 footage (hopefully, that's possible). Assuming that goes well, add the Insta360 drivers back. If that does well, add RSMP Pro. There have been several forum posts about issues with AEJuice. Before re-installing that, check with the publisher about which version is rcommnded for use with 2025 (25.1.0 Build 73). While doing this troubleshooting, keep Time Machine disabled so that you can do a complete restore from before you started the clean install process should you decide to revert to that. Assuming you're able to get back to things working as expected, restore just your Documents and configure Time Machine to backup as usual.
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