P: Photoshop 27.10: "Edit in Photoshop" from Lightroom Classic & Lightroom Desktop does not load image with Denoise

Did you Denoise the images? If so, this could be the issue: 

**Summary**
In Lightroom Classic, "Edit In > Open as Layers in Photoshop" with two edited Nikon NEF files makes the whole system unresponsive for a long time. The same two unedited NEFs open as layers normally. Exporting the edited files as 16-bit TIFF from Lightroom and using Photoshop's "Load Files into Stack" works fine, so the edits themselves render correctly. The problem appears to be in the Open as Layers handoff.

**Steps to reproduce**
1. Select two edited NEFs (high ISO, 64000) with [list edits, e.g. Denoise / AI masks / Dehaze +57 / Clarity +55].
2. Photo > Edit In > Open as Layers in Photoshop.
3. The system freezes. Processor use stays under 10% and memory around 80% of 32 GB.

**Expected:** Photoshop opens a two-layer document, with a progress indicator while Lightroom renders.
**Actual:** The whole PC becomes unresponsive, with no progress indicator and no way to cancel.

**System**
- Windows 11 25H2 (build 26200)
- AMD Ryzen (3D V-Cache), 32 GB DDR5-5600
- AMD Radeon RX 7900 XTX 24 GB, Adrenalin 26.9.1 (clean install, Factory Reset)
- NVMe SSD for OS, catalog, Camera Raw cache (50 GB) and scratch disk
- Lightroom Classic [version] / Photoshop 2026 [version]

**Already ruled out**
- Photoshop Beta (uninstalled) and regular Photoshop both affected
- Photoshop started with third-party plug-ins disabled: still freezes
- Graphics processor turned off in Lightroom and Photoshop: still freezes
- Source files copied from the HDD to the NVMe drive: still freezes
- Integrated Radeon graphics disabled; clean GPU driver reinstall
- Windows Defender scans clean

**Please address**
1. Open as Layers hanging or locking the system with heavily edited raw files, when Export to TIFF of the same files works.
2. No progress indicator and no way to cancel while Lightroom renders files for Photoshop.
3. A related issue: uninstalling Photoshop Beta removed Lightroom's link to Photoshop 2026, so Open as Layers, Merge to Panorama and HDR were greyed out until I reinstalled Photoshop 2026.

I can provide sample files and system info if helpful.

I got a Photoshop 27.10 update yesterday. Strange, because 27.10 was already installed (I did not downgrade). I ran the update and this seems to have fixed the issue. A denoised iPhone 17 DNG, sent from Lightroom Classic, opened just fine in Photoshop. Is this an official fix (if so, why no change in version number), or purely coincidence?

You posted in the wrong forum. Version 15.5.1 is Lightroom Classic, not Lightroom ecosystem. Is this your problem?: https://community.adobe.com/bug-reports-711/p-photoshop-27-10-edit-in-photoshop-from-lightroom-classic-does-not-load-image-1639250

Known issue (although for me a Photoshop update yesterday seems to have fixed it):

https://community.adobe.com/bug-reports-711/p-photoshop-27-10-edit-in-photoshop-from-lightroom-classic-does-not-load-image-1639250

I get repeated denoise errors. My camera raw version 18.5.1 is not working with the Lightroom version 15.5.1.

Open a file in Lightroom.

Apply denoise to the file.

Export the file to Photoshop using Command E or the menu item Edit in Adobe Photoshop.

Photoshop opens but the file is not loaded.

Go back to Lightroom, step back in history to remove the denoise step.

Export the file to Photoshop using Command E, this time the file opens in Photoshop.

Lightroom Classic 15.5.1 Adobe Photoshop 27.10.0

After further investigation it appears 26 files taken with my R1 on the same afternoon seem to be affected. Images taken after those 26 do open in PS with denoise applied. Same camera, lens and day. I have no idea why only these files seem to be affected?

Exactly same issue, I had to disable the “denoise”, but that isn’t a solution, this needs to be solved.

Known issue:

https://community.adobe.com/bug-reports-711/p-photoshop-27-10-edit-in-photoshop-from-lightroom-classic-does-not-load-image-1639250

Can you launch the Photoshop application successfully on its own without Lightroom? What happens if Photoshop is already open when you select “Edit In?” 

If opening Photoshop first doesn’t work, let’s have a look at your Preferences as seen in Lightroom Preferences > External Editing (as shown below):