P: Program error when saving, lag when zooming, changes not reflecting in document window (macOS)

I'm having the same issue. Running Windows 10 - I can save the file if I hide all layers, but as soon as any layers other than the background are visible, I get the program error message when trying to save (in .psd or .jpeg formats). I can't flatten or merge layers either - I just keep getting the error message.

I reverted to version 22.0.1 - and that seems to have fixed the issue for now. Will definitely be waiting for further information to ensure the bug is fixed before upgrading.

Since a few weeks ago, i have been having major issues with photoshop (2021)
before then i have been using it for about 2 years with no issues whatsoever.
to start with, every now an again, it would come up with an "could not save *file name* because of program error" and not let me save my file, making me lose alot of artwork. I tried multiple things to fix this issue, but nothing has really changed. Earlier today a white line appeared at the top of my canvas/workspace and although it was pretty irritating, it wasn't causing any big issues, however after trying to draw for about 10 minutes, more lines have appeared and make it really hard to draw. it eventually got so glitchy everytime i zoomed in and out, that the program is practically unusable for longer than 5 or 10 minutes.
If there is any solution to this, please let me know!

I am getting this message for a project I created last night. Worked on it for hours ! I'm in Photoshop daily and have never encountered until last night. I went into my Mac security and privacy settings and added Photoshop, I've attempted to save to a dozen other locations on my MacBook. And to make matters worse, this morning when when I attempt to merge layers, select images, or copy layers, the same message is popping up which has rendered my Photoshop App completely useless. What do I do? Have I lost an entire evening of work ?

@JeffreyTranberry Yes

@James, @10065094_,  @17499214, Thanks. Will get you added over the weekend.

@JeffreyTranberry For some weird reason I am only having these problems when using the 8bit channel. If I use the 16bit channel everything seems to work okay for me. Hope this helps you figure out the problem, and thank you for trying to find a solution. 

I am also facing the same issue. Please include me as well for the invite.

@JeffreyTranberry

Iam having the exact same issues and its very frustrating. Ive been a photoshop user for over 9 years now and this has been the worst situation ever. Please include me in any pre release or a fix for this bug. Im using a PC with Windows 10 and Photoshop 22.1 

I am also having these exact same issues, which was a totally frustrating situation. I would like to be a part of any fix or pre-release that will help with the remedy of this bug or whatever it is. I have been using photoshohp for 9 years now and this is a big let down. I use a PC running windows ten and photoshop 22.1

Workarounds worked briefly, but now PS 2021 simply crashes. The only thing that works for me is reverting to PS 2020. Am on a Mac, running latest OS (Big Sur) with latest update.