after effects 2018 not opening

Hi defaulto43kd770aewq,

Sorry for your issue.

As mentioned by the expert, please share your system specifications (CPU, GPU, RAM, OS). Also, please check if it generates any crash report: https://community.adobe.com/t5/after-effects/faq-how-to-find-after-effects-crash-logs-on-your-computer/td-p/10333124?page=1 

You could try changing the permission as mentioned in the following article: https://helpx.adobe.com/in/x-productkb/multi/preferences-folder-read-only-error.html 

Let us know how it goes.

Thanks,

Nishu

Please give us system specifications and operating system.