adobe acrobat cannot open in protected mode due to an incompatibility with your system configuration

There is a key under HKLM/SOFTWARE/POLICIES/ADOBE/ACROBAT/DC/FEATURELOCKDOWN 

Here ensure bUseWhitelistConfigFile value is present , it should be a DWORD value and value should be set to 1.

Hi @Grinbit 

Sorry to hear about the trouble caused.

Does Acrobat open even for a couple of seconds or crash immediately? If you can launch it, then, 

• Navigate to Reader>Edit>Preferences>Security (Enhanced)>disable "Protected Mode at Startup" and "Enhanced Security">OK>Reboot Reader [Windows only]

Note: these changes are only for testing purposes. Once tested, please change it back to the previous setting.  

• If you have any antivirus installed, then disable it for a while.

If nothing works, then, 

• Run this cleaner tool to remove the existing installer and application’s file traces:

https://www.adobe.com/devnet-docs/acrobatetk/tools/Labs/cleaner.html

Download the Acrobat Reader installer from here:

https://get.adobe.com/reader/enterprise/

Thanks,

Akanchha