Links in PDF containing # not working in Safari

We are trying to include a link that contains the character '#' in a PDF. 

The link is https://pmlib.org/cuentame-tu-historia/#top

PDF attached.

Links appear correct in Acrobat, and work in Chrome and Edge. 

However, in Safari, when you click on the link in the PDF, it renders it as "https://pmlib.org/cuentame-tu-historia/%23top" and gives back a 404 error. 

Anchor links do usually work in Safari (when accessed from the website or from the body of an email).

Does anyone know what causes this or how we could fix it?