Well.... we fought this and fought this. Poured through the countless forums going back years... and we actually found something that fixed (for us) this exact issue.
This is for Windows 10 running Adobe X and DC, PDF's opened from the network (locally opened PDF's are fine) have random blank pages after sitting idle for some time.
Troubleshooting Done: Reinstalled Adobe, even used the Adobe Cleanup tool. Was using X Standard, so tried using a trial of DC. Tried different profiles on the computer. Reinstalling Windows was not an option.
We were having an issue with some Tax software crashing randomly. Support for said software informed us of a problem if Group Policy was using "Replace" to map network drives. Apparently Microsoft changed the way that Replace behaves via Group Policy on Win 8, Win 10, and Server 2012 machines and now says to use "Update" to map the drives.
After resolving the crashing tax software issue it occurred to us maybe PDF's are also being affected by the "Replaced" mapped drives. We changed GP to use "Update" rather than "Replace" and low and behold network opened PDF's have been open for over 24 hrs without an error, blank page, or single hiccup. This resolved our issue, and I really hope this helps some others, as it has been a head scratcher. Good luck!!