Adobe reader cannot open in protected mode due to an incompatability with your system configuration.

Hello there!

I am having exactly the same problem. Tried uninstalling and reinstalling too many times. I tried removing files and folders manually, cleaning with ccleaner after uninstallation. In addtion to these I also tried uninstalling with adobe removal tool. I rebooted everytime before downloading a fresh installation.

My OS is Windows 10 Professional Version 1803 and build 17134.48 on a Microsoft Surface Pro 3.

I also tried TDSSKiller but it doesn't find anything. I am an IT guy and OK with using a computer without having any rootkits, malicious software, viruses etc. Even though I am using enterprise version of Sophos for protection. It also found nothing. That is why I do not think that this is the issue.

Only thing that I can think of is Surface Pro 3 is pending for an update for security processor (TPM). On microsoft's website they say the patch will be available for download soon.

Could this be the issue? Maybe I am having this problem because of the lack of security update of my surface pro 3 processor?

Can you open Adobe Reader by itself?  If so, try disabling Protected Mode [Edit | Preferences | Security (Enhanced)].

If not, tell us your operating system and Reader version.