Many people are experiencing problems with LR 10.0, 10.1, and 10.1.1 on all versions of Mac OS. Adobe has acknowledged these issues, and we can hope that 10.2 will fix them. LR usually releases every two months, and 10.1 came out on 12/8, so we might expect 10.2 the first week of February. However, 10.1.1 was an unusual "patch" release to fix a cloud-sync problem, so the regular schedule might have shifted (Adobe rarely lets us know ahead of time).
There may be multiple issues going on, so different workarounds have worked for some people:
- Set Preferences > Performance > Use Graphics Processor to Off.
- If you have a custom color profile assigned to your display from a calibrator or running System Preferences > Displays > Color, set the display profile to Color LCD (for a Retina display), Adobe RGB (for a wide-gamut display), or sRGB (for a traditional display).
- Roll back to 10.0 (easy):
https://www.lightroomqueen.com/roll-back-update-previous-classic/
- Roll back to 9.4 (hard, ask for details if you get this desperate).
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