ADJUSTMENT LAYERS ARE NO LONGER IMMEDIATELY USABLE WHEN OPENING A FILE. Photoshop 24.6.0  release /

So I had the same problem and it turns out the you just have to change the file bit size. Like I transfered a file from a laptop that had photoshop 19 and to a desktop photoshop 24. The file was in 32bit from photoshop 19 and I changed it to 8bits and now its working fine! All the adjustment layers are not grayed out now and totally usable!

@ystudio219219362ch5 

Perhaps try a thorough reset of Photoshop preferences?

(read this entire post before acting please)

Resetting restores Photoshop's internal preferences, which are saved when Photoshop closes.

If they become corrupt then various issues can occur.

Here’s some info on how to do that:

https://helpx.adobe.com/photoshop/using/preferences.html

Manually removing preferences files is the most complete method for restoring Photoshop to its default state: 

https://helpx.adobe.com/photoshop/using/preferences.html#Manually

Manually removing preferences files is the most complete method for restoring Photoshop to its default state. This method ensures all preferences and any user presets which may be causing a problem are not loaded.

1. Quit Photoshop.
   
   
2. Navigate to Photoshop's Preferences folder.
   macOS: Users/[user name]/Library/Preferences/Adobe Photoshop [version] Settings
   Windows: Users/[user name]/AppData/Roaming/Adobe/Adobe Photoshop [version]/Adobe Photoshop [version] Settings
   
    
   Note: The user Library folder is hidden by default on macOS. To access files in the hidden user Library folder, see How to access hidden user library files.
3. Drag the entire Adobe Photoshop [Version] Settings folder to the desktop or somewhere safe for a back-up of your settings
   
   
4. Open Photoshop.
   
    New preferences files will be created in their original location.
   

Note re macOS: The user Library folder is hidden by default.

To access files in the hidden user Library folder, see here for how to access hidden user library files.

https://helpx.adobe.com/x-productkb/global/access-hidden-user-library-files.html

Unexpected behaviour may indicate damaged preferences. Restoring preferences to their default settings is a good idea when trying to troubleshoot unexpected behaviours in Photoshop. check out the video

https://helpx.adobe.com/photoshop/using/preferences.html#reset_preferences

Learn how to access and modify Photoshop preferences and customise per your frequent workflows

https://helpx.adobe.com/photoshop/using/preferences.html

And here’s an earlier forum discussion as an aid to understanding

https://community.adobe.com/t5/photoshop-ecosystem-discussions/quick-tips-how-to-reset-photoshop-preferences/td-p/12502668

You may want to backup your settings and custom presets, brushes & actions before restoring Photoshop's preferences.

Here is general info about that:  https://helpx.adobe.com/photoshop/using/preferences.html#BackupPhotoshoppreferences

Before you reset your preferences

in case of future issues, I suggest you make a copy as Adobe may need one to check problematic references. 

Quit Photoshop.
Go to Photoshop's Preferences folder

Preferences file locations: https://helpx.adobe.com/photoshop/kb/preference-file-names-locations-photoshop.html\

  [on MacOS see: Users/[user name]/Library/Preferences/Adobe Photoshop [version] Settings

  Note for those on macOS: - be aware that the user Library folder is hidden by default on macOS.

  https://helpx.adobe.com/x-productkb/global/access-hidden-user-library-files.html

  In the Finder, open the “Go” menu whilst holding down the Option (Alt) key.

  Library will now appear in the list - below the current user's “home” directory. ]

Now you can drag the entire Adobe Photoshop [Version] Settings folder to the desktop or somewhere safe as a back-up of your settings.

Note for those on macOS:

Preference preservation is affected by macOS permissions,

you’ll need to allow Photoshop ‘Full Disk Access’ in your Mac OS Preferences/Security and Privacy

If that doesn't fix the issue:

Go to Preferences > Performance... and uncheck Multithreaded Compositing - and restart Photoshop.

Still hanging? 

Go to Preferences > Performance... click Advanced Settings... and uncheck "GPU Compositing" - then restart Photoshop. 

Do you still have problems?

It may even be time to reinstall Photoshop.

It’s recommended that you use the Adobe CC cleaner tool to remove all traces first.

(See above about preserving preferences though! It’s worth preserving them unless they are corrupted.)

https://helpx.adobe.com/creative-cloud/kb/cc-cleaner-tool-installation-problems.html

Uninstall Photoshop BUT make sure to choose the option “Yes, remove app preference”.

Once that process finishes, start the installation process and look into the “Advanced Options”. Uncheck “Import previous settings and preferences” and choose to “Remove old versions”.

I hope this helps
neil barstow, colourmanagement net - adobe forum volunteer - co-author: 'getting colour right'
google me "neil barstow colourmanagement" for lots of free articles on colour management
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I'm having the same issue, sometimes I need to reestart ps 2024 5 times a day, sometimes it happens in the middle of a work in progress and i need to save, reestart and open again. I can't make it work clicking around like you, it has to be closed down and opened again. I reeinstaled photoshop and it didnt solve the bug. I can see the issue for you started in June 2023, so even before photoshop 2024.

My apologies! I was looking at some old information regarding the release of 24.6, but I did read that there will be an update later this week.

Just an FYI 24.6 is Beta.

Thank you for letting us know you are having this issue.

From a thread I just read a few moments ago, there should be an update released later this week. Until then, you might want to use the latest non-beta version to be able to keep working.

Michelle