Images Lose Sharpness when viewed in any other program

[First_Person]

Images look sharp in Photoshop. After saving, the saved image appears slightly blurred in every image viewer I try. The file type doesn't matter. I've tried saving as PNG, TIFF, and Jpeg with the same result - It always appears slightly blurred after saving.

If I open the saved file in photoshop again, it appears sharp. Here's a screenshot of the same image opened in photoshop and irfanview at 100%.

[Mylenium]

Nopthing to do with sharpness. PS simply brings out more noise and produces a more contrasty image, which indicates that your system does not use color management and/ or you have set it up wrongly, so the results don't match. As a start you should therefore read the respective sections of the online help and check your settings:

https://helpx.adobe.com/photoshop/using/understanding-color-management.html

Mylenium

[Per Berntsen · Accepted solution]

Irfanview is color managed (as long as color management is enabled), and even if it wasn't, it would not affect sharpness and noise at 100% view. 

All applications should display the same sharpness and noise level at 100%, although those without color management will display wrong colors.

The Photoshop images are not only sharper than Irfanview, but also have a lot of noise.

I suspect that Photoshop is wrong here, and that Irfanview displays correctly. 

@First_Person : First of all, make sure that Cache levels is set to at least 4 in Preferences > Performance.

If that's not the issue, try unchecking Use graphics processor, also in Preferences > Performance.

If this makes Photoshop display like Irfanview at 100%, update your graphics driver, then try to enable the GPU again.

When posting screenshots, please use the Insert Photos button in the toolbar.

[First_Person]

Thank you! Unchecking Use graphics processor fixed the problem. 

There was a box checked by default in AMD Adrenalin that sharpens images in games. With that unchecked, the problem is fixed.