Questions about setting for a large project


Hello, I usually print a large image up to 60 inch at the longest but I have questions to clear some answers.
1. When do I use 16 bit or higer? Does it affect when I print it?
2. Do you think it's ok to set both color profile and color setting with ProPhoto?
3. What does send a 16-bit data do for printing?
4. For a long term storage, do you recommend higher bit and wider color space?
5. If I want to create a canvas with twice bigger than 60x44, do I still keep 300 PPI?
6. Is there a way to show preview with PSB files on MacOS with Apple Silicon?
7. What's the best way to reduce file size if I have more than 100 layers?
