When I work with the Mixer Brush, I really miss that it blends to transparency. If I create a layer above and start painting, the Mixer Brush changes its behavior quite aggressively. I end up avoiding the creation of layers and hampering the flow of my work a little.
The "Sample All Layers" option doesn't work for me, as it leaves Photoshop too heavy and brings tones that I don't want. Upper layer textures and other information spoil the sample.
For me it would be perfect to have the options "Blend to transparency", to be able to paint on layers above without being influenced by others and maintain the behavior of the brush, and "Blend to underlayer colors", which samples only layers below, without considering above.
A good reference for these options is how Paintstorm Studio does it.
I have attached the examples