What workspace are you using? If not already set to Essentials, switch to it, and reset Essentials.
The Motion workspace can be a pain regards shortcuts, for instance. You mentioned Ctrl N, and that's one that does not work in the Motion workspace.
When you get things set how you want them, then be sure to save as a Cusatom workspace with these options. It's a great way to save your custom shortcuts and toolbars.
I have been having issues with the beta version and window focus. If the document window does not have focus, then shortcuts might not work. This is too intermittant to be even close to be sure about, but AFAICT it only ever happens with the beta version.
What keyboard are you using? Does it have a gaming function that lets you turn off a bunch of keys?
Are you using something like G-Hub, Synax, or i-Cue, and if yes, does it have app specific profiles? If yes, then you are probably going to need seperate profiles for release and beta versions.
When Edit > Shortcuts says that a shortcut is already used for something else, you do know that you can ignore that?
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