I agree w/ Myllenium that unless you have a super-beefy system, you're likely going to run into some processing slowdowns if your content is heavy at all. (Pre-rendering will be your friend here.) That said, it looks like your actual working space is only about 6800x4400, so you might be ok.
I'm assuming by "image" you actually mean "video" or "motion content," so imagine that the "slicing it up in Photoshop" suggestion may not be an option here.
I'd start by making this layout comp like I suggested above. For content that needs to stretch across multiple screens, you can then kind of reverse-engineer that to position that layout map into each individual screen. If this is intended to be one large cohesive image, that'll likely be easier to work with anyway. Make yourself some grids, create shape layers with bright red edges, give yourself clear labels, etc., so you can clearly see where everything lines up, even when you're positioning those things within precomps. There's a certain amount of manual setup involved in a bespoke multiscreen layout like this.
If at all possible, I'd recommend doing some tests with easy dummy layers on the actual hardware setup before you spend 100 hours making your time-consuming content all perfect. Failing that, try to build things in a way that you'll be able to nudge things around later WITHOUT having to rebuild stuff from scratch.
... View more