P: Program error when saving, lag when zooming, changes not reflecting in document window (macOS)

No se ha podido guardar poiché...

the good translation in italian is:

Non è possibile salvare perché...

I am having this same issue. Since updating to the latest version, I can't merge layers or save any work. This is costing me time and money. FIX THIS NOW!!!!

Quando provo a salvare un file psd mi dice "impossibile salvare il file... poichè si è verificato un errore del programma". Sistema operativo Mac BigSur.

Sempre que vou em "Salvar como" o photoshop não me permite e aparece a mensagem de "Não foi possível completar seu pedido devido a um erro de programa". Já desinstalei e instalei umas 3 vezes e não resolve este problema. Pago a Adobe para não acontecer este tipo de problema e aparentemente não ajuda em nada.

Try hiding all layers, or all layers but the background layer, and resaving. It worked for me.

I'm compositing an image with multiple layers and it won't let me save! It keeps saying 'cannot save sure to program error'? I can't do anything about it except lose the work I've done and restart Photoshop!??! Please help!!!

UPDATE: So I tried once again. Closed the file. Opened it again. Dragged the three items out of the folder. Saved it. Went fine. Then created a new folder. Dragged the items in there. Saved it. Went fine. Then added brightnes/contrast layer. Saved... fine. Then applied Clipping mask to the folder and this is where it always goes wrong. Can't save anymore.

Luckily for some reason now it did work BUT it's just waiting for this to happen again as this is not the first time it happened! Creating clipping masks on items/folders gave me this problem many times before and it's bound to happen again!!

Everything goes fine with editing an creating my files. BUT as soon as I create a cliupoping mask on a folder (with brightness/contrast effect) then I can't save anymore. I get this message 😞

- Could not complete your request because of a program error

Tried to google the problem and tried different settings but nothing helps. Tried making a new file to see if the file was corrupt but again failed. I have the latest photoshop. All is up to date. Working on mac osx catalina 10.15.7

Hope someone knows a fix.

@JeffreyTranberry

I have been able to repeat the bug make 30 layers than on the 30th layer draw on it and save it then move that drawn layer and transform it then try saving it. I'm using Photoshop 22.1 on Windows 10  

I'm having the same issue.