Premiere Pro crashing at the most random times of simple editing

That's a pretty decent troubleshooting bit there. And a good post about it.

Your system seems to run quite differently than mine, which is a 3960X with 128GB of RAM and a 2080Ti. The main difference seems to be that AMD GPU.

My rig doesn't have issues with Alt/Tab. So yes, it might be that the AMD GPU is problematic. Or a driver issue. I know there have been reports that although Premiere is running better now on AMD GPUs than it used to, it still runds better on most later Nvidia GPUs. Which is why I went with Puget's suggested GPU.

Yet among the apparently several million PrPro users, there have to be a fair amount with AMD GPUs. Why are some having issues, and others not so much? That's the kind of thing that I can't answer, and drives me batty. Variability between users.

Neil

Correct. However I wouldn't see how avoiding nests should solve my problem. Nesting is an official Adobe feature right, shouldn't that just work properly?

With opening the multicam do you mean opening the multicam-view in Adobe right? I get that you're suggesting a better workflow, however I feel comfortable with mine and i'll surely look into it when I've got the time but for now I just got too many projects to finish. 
I'm using the nests to speed up my syncing process. Because if I had to leave all clips seperate following eachother I'd have to put cuts in the BRAW footage to each sync them up.

Also the whole sequence has already been edited, which is an edit of 30 mins long. I'd like to avoid redoing that whole edit as it would cost me days again. For now the only option seems to avoid alt-tabbing. AKA not getting distracted by other browsers and programs and using my laptop besides my PC to look things up. This until Adobe fixes it's stability.. which lately seems to be following the same line as the western world's health..downwards.

Hi Neil,

It's all Panasonic Gh4 MP4/MOV H.264 4:2:0 footage and Fujifilm XT-4 MP4/MOV H.264 4:2:0 (Full Range) footage. When doing long recordings (30 mins) these camera's split up 30 mins into multiple clips. I use nests inside premiere pro to make them one long take again. (see the picture included)

However I do think it might have something to do with either the blackmagic raw filetype (12:1 compression) or the large filesizes. (It's stored on a relatively new (2022) 4TB external HDD, brand: WD elements) 
And it only happens when I use alt-tab to check my browser or open another program and then try to continue back in premiere pro. As long as I stay in Premiere Pro no crashes occure, footage runs fine with about 20fps a few stutters but nothing too crazy. Adjusting lumetri works fine and editing seems smooth. But whenever I switch to another program or to my browser and come back it either freezes, stops rendering the program view or crashes. 
This is also why I suspect it has something to do with large file sizes or BRAW footage, because when working in smaller a smaller project with only 2 recorded livestream clips of MP4/H.264 (both clips are aprox 60mins) no crashes seem to happen and everything works fine when I alt-tab or switch to another program or to my browser.