This doesn't look at all like a problem related to Adobe Acrobat.
Unless, there is something that Acrobat does during an initial install or during updates that we are not aware of, anything that you do to a Microsoft Windows registry is basically too advanced for the average computer user, specially if you don't even have a clue of what is the root of an error message, and where to start looking for clues in your own computer.
Before self-proclaiming yourself as a victorious registry "hacker", always consult with additional official Microsoft guidance.
I suspect this issue is not exactly an error, but a security layer that was added with newer versions of Windows 10, in which the operating system will only allow to install or find programs to handle specific files and documents, but ONLY if such programs are trusted and offered through the Microsoft Store.
If this would be the case, and before you decide to fool around with registry hives, also check if your version of Windows 10 has S mode enabled.
To disable S mode, refer to the steps described in the following link: