Anya said: "Wow that is really cool. Thanks."
Well, it's just a proof of concept.
Note: I did not test anything else, especially not, if InDesign's optical kerning does its job right in this situation. A minimized solution using this idea would be to create a font that has all glyphs from A-Z and a-z where only the first character in a paragraph is substituted with a GREP Style through the applied paragraph style. This would work for situations where every paragraph is only one line of text. A headline perhaps, followed by a subhead. All other text will be set with the original font.
Below the comparison of my special Heuristica Regular without side bearings and the original one.
I used metric kerning and no tracking with the original Heuristica:

Hm. The original Heuristica used in the right text frame needs more love with built in kerning values. InDesign's optical kerning will do a better job, but still needs some tweaking as you can see with the "DE" combination in the left text frame where I used my special font created with IndyFont…
Regards,
Uwe Laubender
( ACP )
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