When I create a .Pdf from an inDesign file, main image disappears when opened in a Chrome Browser

Hi @Mark Maglio , Browsers can have trouble with live transparency effects—try exporting a flattened sRGB PDF. Set the Output tab to this:

First off, if the PDF looks okay in Acrobat or Reader, the issue is going to be with viewing it in a browser. That said, a picture does us no good. What were your PDF export settings? Even better, please post the PDF so we can take a look at it.