Premiere just can't handle a sequence with uneven framerates mixed (e.g. 50.00 fps + 29,97 fps).
Once I drop a few effects on clips, it's done. Just freezes for a few seconds, then unfreezes, untill I scroll back to that section where mixed framerate clips meet, and freezes again.
File type doesn't make any difference, it can be even 720p 422 proxy
Am I the only one? Nobody had ever talked about it.
M1 Max.
Tested on many premiere versions, on many machines.
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