P: Program error when saving, lag when zooming, changes not reflecting in document window (macOS)

@JeffreyTranberry Layers is on - can't save. Layers off - can save. Can't merge.
What's so difficult tracking this?
Simply trying to place more hair, less than 400mb psd, background and 2 layer&mask only.
I did a more than 4GB psb with more than 25 layers with render, copy and such in october, and didn't had a single problem.
Sorry for it, not wanting to bitching about it, but this problem driving me crazy, can't work, I can't belive in 2020 "there is an error" kind of messsages still exist not knowing what's the problem.
I know I'm only a hobbyist, but it looks like a common problem not a rare one... And to be honest, I pay a good amount of money for it.
As I read and experienced, it is like this for weeks.
Version 22.1 on Win10, full pack, having problem since the latest update.

See compatibility issues here: https://helpx.adobe.com/photoshop/kb/photoshop-and-macos-big-sur.html#big-sur-known-issues

This is very challenging and annoying, whenever I start creating lots of layers (necessary for my artwork), photoshop bugs out and says "can't save file due to program error". I've had to uninstall and reinstall Photoshop, try a bunch of different external drives, and it will work temporarily and then all of a sudden go back. The only solution I've seen on here that works is making all your layers invisible and except the background layer and saving. But I'm worried about my work if this continues. 

Is this a bug? Or problem with my computer? 

Many people have been reporting problems with PS errors since updating to macOS Big Sur (11.1). I hope Adobe fixes this soon!

Hi, hoping to get help. My photoshop 2021 won't let me save my file when I place smart objects or even convert my layers as smart objects in the file.

it look like that has something to do with smart objects which are lager than the work surface. if i remove the information outside the work surface in the smart object. if i delete the pixels out of the work surface of the smart object, i reduce the smart object to a layer in the psd or i set the the bit mode from 8 to 16 bit i could safe the psd..

but with the typical setting of 8 bit with wrapped smart objects (which are bigger than the work surface of the smart object and not background reduced i get the error "couldn't save because of program error".

my system: win10 20h2 with a amd 5800x and a nvidia rtx 2060s

I'm working on some PSD's in Photoshop 2021 which are around 200MB (so not big at all) and 90% of the time I try to save or export my PSD, I can't save it because of a program error. I've restarted my laptop and Photoshop a several times and changed the work station, but it doesn't change anything. I've also took a loot multiple trouble shooting blogs here at Adobe, but nothing seems to help. This is really frustrating since I have a deadline and I can't get any further at this moment.

@JeffreyTranberry I would love to be added to special build list.

Do we know how far back for versions we need to go to have this not cause issues? Eg 22.0.1 vs 21.2.4

I have a set of CR2 photos that I have pieces of 2-4 added to the last. It saves fine for X amount of time with me manually saving it every few minutes. But as soon as I notice it having trouble zooming or scrolling I can't save unless I turn off all but the background layer. This particular time had 5 layers, earlier tonight had 3 layers.

I'm using Windows 10 Pro on a rather new Precision with a Xeon and a Quadro. A support chat person said the workaround was to disable 'Use Graphics Processor' which basically makes photoshop non usable with large photos.

I had a chat with one of Adobe's arrogant service reps and he sent me a link that had me try to enable "Full Disk Access" and the Hide All Layers work arounds, neither of these worked. The third option did work and that was to disable the Discover panel.

• Quit Photoshop
• Navigate to the following location:
• On macOS: navigate to "/Applications/Adobe Photoshop 2021/Adobe Photoshop 2021.app/Contents/Required/UXP/"
• On Windows: navigate to "~\Program Files\Adobe\Adobe Photoshop 2021\Required\UXP\"
• Rename the "com.adobe.unifiedpanel" folder to "~com.adobe.unifiedpanel"

Restart Photoshop and it should work now.

Can I be added to the fix list Jeffrey? 
Same issue, but just started happening this week (I've been on latest version).