Yes! I do that all the time - for a quick way to get my files off the card and into the computer. My older Nikon uses SD cards, so I have a fast SD card reader, and just plug that in and copy to a folder on my hard drive - no real need for a secondary drive, unless you want one. There's one disadvantage to that though. The files lose their creation date/modification date. NOT in the EXIF - that's fine, but on the computer it only records the date the file was created in the folder. That may not be a big deal for you, but I use this program that lets me correct the dates (and when I forget to change my camera's timezone, the times, too) to match the EXIF data, so it's quick and easy and done. In fact, when doing it this way, I also use a related program to rename my files in batch as well (although, you can do that with Bridge, too). So, instead of DSC_5634, I can name it by date and event. The programs I've liked for this are A Better Finder Attributes (for changing dates and times), and A Better Finder Rename. They're by publicspace.net. I find them SUPER helpful for my personal less-than-on-top-of-things workflow.
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