I just moved to 25.4 after holding back on 25.2 for a while. I've got a couple posts about some of these new program monitor changes, like Toggle Direct Manipulation keyboard shortcut not working UNLESS the Program Monitor is active. But now there's a new issue, the Zoom Program Monitor to Fit keyboard shortcut ONLY works if the Program Monitor is NOT active.
Basically, you need to fix these two things.
Zoom Program Monitor to Fit keyboard shortcut needs to work when Program Monitor is active panel.
Toggle Direct Manipulation needs to be something you can turn on and off WITHOUT needing to have the Program Monitor be the active panel.