Render and replace is different than render preview files. In my experience, r&r is the same type of thing as exporting a sequence and then re-importing it as media into the project. If you later delete the sequence in the project, the media will remain. Pr treats the r&r file just like a clip that you import manually to the project, To delete the extracted audio files, you'd have to find them in the project panel, make them offline with the option to delete media files, then delete the offline instances. Not easy or straightforward, but it will get the job done.
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