Is it safe to delete content of the hidden library folder to free space on my mac?

Hi, I'm using an old macbook (macOS Big Sur 11) for editing with Premiere and a bit of Photoshop too. The 1TB HD has been divided and the partition with Applications is 250GB and has the usual structure: Applications, Library, System, Users. I've emptied the Cashes from withing Premiere and the Library folder is about 9GB. The User folder is the problem. It has two subfolders, one of mine and another one Shared (very small), my folder is 160+ GB large. Now I've looked at the hidden folders by using Shift + Cmd + . and found another hidden library folder that is 111GB. Within it is 40+ subfolders...... I wonder if I could delete the content of that hidden library folder, but I'm not sure whether it would be safe to do so. (I have a habit of shutting down my machine, rather than using the sleep mode, and I now wonder if that is a bad habit rather than a good one.) So the large amoung of stuff is not in the Library folder of Applications/Library/System/Users-structure; it is in Users - my folder - Library (and can only be seen using Shift + Cmd + . command). Any advice would be much appreciated. Thanks, Elisa