Do you have the pre-conceived plan for your layout? If yes, you can create the complex frame for your image. In this case, you will use only 1 instance of your image and you can make any small changes like Vinny suggests. 1. Set all needed margins, columns, and other guides. 2. Create all needed rectangles and place them above the image. 3. Use ADD function of Pathfinder panel to create a compound path. 4. Cut the image (Ctrl/Cmd X) 5. Select the path and Paste Into (Edit > Paste Into) your image You can do it on your current page or on the Master page, on any layer etc. And if your idea has been changed, you can use Direct Selection Tool to move any "window" to the new place or even delete it.
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