Run

[Fraol29974154hlmv]

Can I run after effect on Intel i5-4300M which 16Gb Ram .

Gpu0=Intel HD graphics 4600(2Gb)

Gpu1=AMD Radeon HD 8750(8Gb)

[ToolfarmJP]

It looks no problem. If you expect to use a GPU acceleration, Nvidia is preferable.

[Andrew Yoole]

Yes, this should be capable of running the majority of After Effects components without too much problem.  Avoid 4K video and higher if you can, as these will chew through your RAM pretty quickly, especially depending on how complex your projects are.