No, you'd need a version control system to achieve that - if you're editing a topic and then generating help with that topic included (assuming you haven't used conditional build tags or excluded it from the TOC) then your changes are going to end up in the output. A version control system prevents that from happening; while you've got a topic checked out for editing, the original topic still resides in the repo and any output generated would use that content, not the changed topic you still have checked out.
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