Using those artistic stroke brushes is an accumulative resource issue. The more strokes you create with them, the more Animate uses system resources to cache them - at least that's what it can feel like to me. I have experienced some brushes tend to cripple the fastest CPUs faster than others while some brushes seem to fine overall. The fact is, these are vector strokes that are trying to look like raster brushes and they are simoply complicated objects that require resources from the CPU to draw. The more strokes drawn, the more resources it takes. I'm on an M1 running Ventura and Animate seems to do fine using some brushes sparingly while others will lag from the moment I stop drawing so that they can actually render themselves on the stage. I will even get the beachball to spin after a short while. I wish Animate handles the rendering of brush strokes better but I also find switching to View > Fast can help. Moho software does this automatically as it is also a vector drawing/animating application but when authoring artwork using the tools, the preview is auto-aliased to avoid the lag caused by a high CPU-demand. I'm sure my technical knowledge of what's happening behind the scenes is slightly off but overall, these brushes you're using are simply demanding too much from the computer to render with each added stroke. If you use the regular Brush tool, it's much more responsive.
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